Bextra Information
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Bextra Side Effects

Bextra Study Links Drug To Increased Risk Of Heart Attacks & Strokes

On April 7, 2005, Pfizer suspended sales of its arthritic drug Bextra (or valdecoxib), a pain reliever used to treat osteoarthritis, adult rheumatoid arthritis and severe menstrual cramps, on requests by the U.S. Food and Drug Administration and European regulators. Bextra was pulled from the market due to concerns that patients taking the drug were at an increased risk of having heart attacks, strokes and a potentially fatal skin condition called Stevens-Johnson syndrome (known to cause inflammation of the mucous membranes of the mouth, throat, genitals, intestinal tract, and membrane lining the eyelids) and that those potentially fatal side effects outweighed the benefits of the drug.

Bextra®, also know as valdecoxib, is a NSAID (Non-Steroidal Anti-Inflammatory Drug). It is prescribed for the relief of osteoarthritis, managing acute pain in adults, treatment of primary dysmennorhea (severe menstrual cramping), and the relief of rheumatoid arthritis symptoms.Soon after the recall of Vioxx which was in September 2004, the American Heart Association received results of a study which showed that Bextra was associated with heart attacks. In this study, about 6,000 patients in 12 different trials showed that the incidence of heart attack and stroke was twice as high as those taking placebo.

Along with heart attacks and strokes, blood clots or clotting were also shown to be associated with taking this drug. Increased dosage shows to increase these Bextra side effects. Gastro-Intestinal Toxicity was shown to be another Bextra side effect in individuals. More Bextra side effects include life-threatening risks related to skin reactions like Stevens Johnson Syndrome, toxic epidermal necrolysis, exfoliative dermatitis and erythema multiforme.

Since the drug has been marketed back in March of 2002 there have been numerous reports of these Bextra side effects. Steven Johnson Syndrome is an extreme condition which is an allergic reaction to chemicals. It appears in the form of an inflammation of the mucous membranes which could include the mouth, throat, genitals, intestinal tract, and the lining of the eyelids. In many patients the skin reaction is so severe that the skin comes off in sheets. It can also lead to lesions and blisters causing very severe pain and even death from infection. Also in about 80% of cases the reactions affects the eye and leads to blindness.

Toxic epidermal necrolysis is a potentially fatal skin disorder where the skin blisters and the top layer of skin peels off. Exfoliative dermatitis is severe inflammation of the entire surface of the skin. Erythema Multiforme is an eruption of the skin (iris). People who have asthma are at risk for one of the serious Bextra side effects called Anaphylaxis. Symptoms from this can occur within minutes, itching, hives, throat swelling, asthma, irregular heart rhythm, nausea, vomiting, and a loss of consciousness.

S serious Bextra side effects include:

* Abdominal Pain
* Indigestion
* Nausea, vomiting and heartburn
* Upper Respiratory tract infections
* Diarrhea
* Unexplained weight gain
* Headaches
* Swelling or water retention
* Fatigue or lethargy
* Yellowing of the skin or eyes (jaundice)
* Flu-like symptoms
* Ulcers, stomach bleeding, any other unusual bleeding
* Stevens-Johnson Syndrome
* Heart Attack
* Stroke
 

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